Safety / Production

Berinert safety profile1-3

  • 30 years of international use4
  • Constantly screened for emerging pathogens3
  • No proven cases of virus transfer5
  • Proven track record established in more than 500,000 treatments6

Berinert production

Berinert undergoes a 10-stage manufacturing process including 2 dedicated virus reduction steps3

  • Pasteurisation (60°C for 10 hours)
  • Nanofiltration (20 nm and 15 nm filtration)

The nanofiltration step proven effective against:

Enveloped viruses
• HIV • HBV • HCV
Non-enveloped viruses
• HAV • Parvovirus B19

References:
1. Berinert 500 IU SmPC. 2. Berinert 1500 IU SmPC. 3. Gröner A, et al. Transfusion 2012. 52:2104-2112. 4. Data on file 2009, Berinert 4.0. 5. Data on file 2009, Berinert 5.0. 6. Craig TJ, et al. J Allergy Clin Immunol. 2011;66: 1604-11.